Single isoform recombinant actin proteins for your research
Discover our single isoform recombinant actin proteins
Single isoform actin proteins for your research
Why Single Actin Isoforms?
1. Studying Isoform-Specific Functions
Different actin isoforms have unique biochemical properties and interact with distinct regulatory proteins.
Example: α-cardiac actin (ACTC1) is crucial for heart muscle contraction, whereas β-actin (ACTB) is essential for cell motility and cytoskeletal integrity.
2. Understanding Actin-Myosin Interactions
Purified actin isoforms allow researchers to examine how different types of actin interact with myosin and other motor proteins.
This is particularly important for muscle contraction studies and drug development for cardiac diseases.
3. Investigating Actin-Associated Proteins
Many proteins regulate actin polymerization, depolymerization, and crosslinking.
Purified actin isoforms help identify isoform-specific interactions with proteins like tropomyosin, cofilin, and formins.
4. Studying Disease Mechanisms
Mutations in actin isoforms cause various diseases (e.g., hypertrophic cardiomyopathy (HCM), actinopathies, and cancer).
Studying purified mutant vs. wild-type actin provides insights into disease progression and potential treatments.
5. Drug Development and Therapeutic Research
Many drugs target actin dynamics, such as cytochalasins (actin inhibitors) and jasplakinolide (actin stabilizer).
Testing drugs on specific actin isoforms improves drug selectivity and efficacy, reducing unwanted side effects.
6. Structural and Biophysical Studies
High-purity actin is crucial for X-ray crystallography, cryo-EM, and spectroscopy studies.
Helps determine the structural differences between isoforms, improving our understanding of actin polymerization.
Applications of Purified Single Actin Isoforms in Research
Research AreaApplicationMuscle PhysiologyStudies of actin-myosin interactions and contraction mechanisms.Cytoskeletal DynamicsInvestigating actin polymerization, bundling, and severing proteins.Cardiovascular ResearchUnderstanding mutations in cardiac actin (ACTC1) and their effects on heart function.NeurobiologyStudying β-actin and γ-actin in neuronal growth and plasticity.Cancer ResearchExploring how actin remodeling contributes to cancer metastasis.Drug DiscoveryScreening actin-targeting compounds for treating heart disease, cancer, and neurodegeneration.
Conclusion
Purifying single actin isoforms is essential for understanding their unique roles, disease mechanisms, and drug interactions. This knowledge is vital for developing targeted therapies for muscle disorders, heart diseases, and cancer.
We provide high-quality recombinant actin proteins for your bioscience research needs. Our proteins are rigorously tested and produced with utmost care to ensure accurate and reliable results.